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17a-Methyltestosterone Quick Details
CAS No.: 58-18-4
storage temp. 2-8°C
Molecular Mass: 302.451
Melting Point:162-168 °C
Sample: Samples Available
Reship Policy: Reship Free
Molecular Formula: C20H30O2
Suitable for: Elderly, Children, Adult, Anti Estrogen
Appearance: white to slightly yellowish-white crystalline
Simple Descriptions About 17a-Methyltestosterone
17alpha-methyltestosterone is a competitive inhibitor of aromatase activity in Jar choriocarcinoma cells and macrophage-like THP-1 cells in culture. The male hormone (17 alpha- methyl testosterone) is dissolved in alcohol at the dose of 60 milligrams per 500 ml of alcohol and then after the alcohol-containing hormone is to be mixed with one kg of dry feed. The treated feed is dried in shade and could be stored in the freezer until used. This one kg of treated feed will be sufficient to sex reverse 5000 fries of Nile tilapia, Oreochromis Niloticus for a 3-week treatment.
17alpha-methyltestosterone is a synthetic androgen with an affinity for the androgen receptor. 17alpha-methyltestosterone is used widely as a component of hormone replacement therapy. Previous reports have indicated that contrary to testosterone, 17alpha-methyltestosterone is not aromatized. However, 17alpha-methyl testosterone still could affect local estrogen formation by regulating aromatase expression or by inhibiting aromatase action. Both possibilities have important clinical implications. To evaluate the effect of 17alpha-methyltestosterone on the expression and activity of aromatase, we tested the choriocarcinoma Jar cell line, a cell line that expresses high levels of P450 aromatase, and the macrophage-like THP-1 cells, which express aromatase only after undergoing differentiation. We found that in both cell lines, 17alpha-methyl testosterone inhibits aromatase activity in a dose-related manner. The curve of inhibition parallels that of Letrozole and gives complete inhibition at 10(-4) M 17alpha-methyltestosterone, determined by the tritium release assay.
|Product Name||17-alpha-Methyl Testosterone||Alias||Android Testred Masteron Meander|
|Chemical Name||Androsten-17-(beta)-ol-3-one 17(alpha)-methyl-delta^4- 17-epi-Methyltestosterone|
|Packing||Secret and discreet package meeting your requirements||CAS No.||58-18-4|
|Characters||White crystalline powder, odorless, tasteless, hygroscopic, light case of deterioration. ethanol solution at 240nm wavelength of maximum absorption||EINECS||200-366-3|
|Use||synthetic androgen with affinity for the androgen receptor, is used widely as a component of hormone replacement therapy||Molecular weight||302.451|
|Storage||Store in cool and dry area and keep away from direct sunlight||Sample||Samples available any time|